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OCR: etion have The factors that regulate vasopressin se been clearly defined (Fig. 5.9), the major fferent determinant being plasma osmolality. D to solutes, however, have varying abilities hd stimulate vasopressin release, Sodium a lutes, mannitol appear to be the most potent s sopressin while glucose has little or no effect on v are secretion. Large quantities of vasopressi volaemia, released after marked hypotension, hyp lycaemia and vomiting. Angiotensin II and hypo pressin both appear to be specific stimuli of vas have been secretion. Although many other factors (e.g. pain, reported to stimulate vasopressin releas atroversial stress, profound emotion), it remains co none whether vasopressin is a true stress hor